We surmise that results obtained from the experiments described in this section cannot serve to understand the role of I_NaL in arrhythmogenesis.

1. Van Driessche W, Lindemann B: Focus dependence of currents through single salt-choosy skin pores in frog epidermis. Nature. 1979; 282 (5738): 519-520 PubMed Conceptual | Copywriter Full Text message

It indicates new good write a reaction paper for money conclusions submit through this manuscript is perhaps not justified and i do not approve the fresh new manuscript inside mode

The new authors enjoys clarified a number of the inquiries I raised in the my early in the day review. Regrettably, all of the big trouble have not been managed by this modify. When i made in my personal past comment, I consider it impractical that every men and women circumstances would be repaired simply of the a number of added paragraphs. Alternatively you can still find certain fundamental concerns towards the experimental design and you can, extremely significantly, with the investigation.

This means this new solid findings put forward by this manuscript are not justified and i also don’t approve the latest manuscript inside form

Brand new article writers possess made clear a number of the issues We raised from inside the my personal past opinion. Unfortuitously, the biggest dilemmas haven’t been handled from this revise. As i manufactured in my prior remark, I deem it impractical that every those activities will likely be set only because of the a few added paragraphs. Rather there are certain fundamental issues on experimental build and you may, very critically, into the studies.

• Best issue is if I implemented the brand new description out-of the ways in the previous type it actually was you’ll be able to in order to decode, which have almost best precision, people arbitrary stimuli labels We picked. Discover to own types of this reanalysis. Regardless of whether i pretend that actual stimulus featured within an after day or are continuously alternating anywhere between rule and you can silence, the fresh new decoding is always alongside prime. This is exactly a sign your decryption has nothing accomplish to your real stimulus read of the Sender it is opportunistically exploiting other have from the studies. This new control analysis the fresh people did, reversing new stimulus names, don’t target this issue since it is afflicted with exactly the same situation. Fundamentally, exactly what the classifier are presumably using is the time who’s got enacted while the tape become.
• The reason behind this really is allegedly that article authors made use of low-independent analysis to own training and comparison. While I understand correctly (discover area step three), random sampling half of information products out-of an EEG trace aren’t separate research. Repeating the study 5 times this new handle study this new experts performed is not an acceptable way to target which question. At random wanting samples off a period collection with which has sluggish change (like the sluggish trend passion one allegedly reigns over this type of tracks below these situations) tend to invariably contain strong temporary correlations. Select TemporalCorrelations.jpg set for 2D thickness histograms and you can a correlation matrix showing which.
• Given that modified procedures point provides more detail now, they remains unclear about just what investigation were used. Traditional category studies declaration just what data keeps (common columns about study matrix) and you may what findings (usual rows) were utilized. Some thing is a feature but generally speaking this might be the new some other EEG channels otherwise fMRI voxels an such like. Findings usually are time facts. Here I assume this new authors transformed the intense examples to your good various other area using principal part studies. This isn’t mentioned if your dimensionality try shorter with the eigenvalues. In either case, I suppose the content samples (obtained at the 128 Hz) was indeed next utilized since the findings and EEG channels transformed from the PCA were used since has actually. The fresh stimuli brands was tasked due to the fact To your or Of for every sample. A collection of 50% from examples (and brands) was then selected randomly to possess studies, plus the other people was utilized for testing. Is this proper?